Krasmutation相关论文
Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant c
Objective: Mutant KRAS, the principal isoform of RAS, plays a pivotal role in the oncogenesis of colorectal cancer by co......
A novel KRAS-NF-κB-YY1-miR-489 axis controls metastasis of pancreatic ductal adenocarcinoma by regul
Over 90%of PDACs are associated with oncogenic KRAS mutations.Besides its well-established role in tumor initiation,onco......
The mutation status of KRAS is a significant biomarker in the prognosis of rectal cancer.This study investigated the fea......
Clinicopathological Features and Prognostic Value of KRAS/NRAS/BRAF Mutations in Colorectal Cancer P
The incidence of colorectal cancer(CRC)is increasing in China,with high mortality.Here,we aimed to evaluate the latest c......
1文献来源Hong DS,Fakih MG,Strickler JH,et al.KRAS G12C Inhibition with sotorasib in advanced solid tumors[J].N Engl J Me......
胰腺癌是人类恶性肿瘤中最为致命的一种,癌基因KRAS的突变,抑癌基因(如CDKN2A、SMAD4)的失活或缺失以及大量信号途径的变化是胰腺......
